The hospital was built in 1900 by the architects, Giles, Gough and Trollope. It opened as the Brecon and Radnor Joint Asylum, in 1903, becoming the Mid Wales Hospital Talgarth, in 1921. It closed in 2000.

The Chapel and hospital complex was photographed during RCAHMW aerial reconnaissance on 2nd Sept 2005, image ref: AP_2005_1834.

T. Driver, 29 June 2007.